The Spirit Molecule investigates dimethyltryptamine (DMT), an endogenous psychoactive compound, which exists in humans and numerous species of plants and animals. The documentary traces Dr. Rick Strassman’s government-sanctioned, human DMT research and its many trials, tribulations, and inconceivable realizations. A closer examination of DMT’s effects through the lens of two traditionally opposed concepts, science and spirituality, The Spirit Molecule explores the connections between cutting-edge neuroscience, quantum physics, and human spirituality. Strassman’s research, and the experiences of the human test subjects before, during, and after the intense clinical trials, raises many intriguing questions. A variety of experts voice their unique thoughts and experiences with DMT within their respective fields.